PINBPA: Cytoscape app for network analysis of GWAS data

نویسندگان

  • Lili Wang
  • Takuya Matsushita
  • Lohith Madireddy
  • Parvin Mousavi
  • Sergio Baranzini
چکیده

UNLABELLED Protein interaction network-based pathway analysis (PINBPA) for genome-wide association studies (GWAS) has been developed as a Cytoscape app, to enable analysis of GWAS data in a network fashion. Users can easily import GWAS summary-level data, draw Manhattan plots, define blocks, prioritize genes with random walk with restart, detect enriched subnetworks and test the significance of subnetworks via a user-friendly interface. AVAILABILITY AND IMPLEMENTATION PINBPA app is freely available in Cytoscape app store. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Cyni framework for network inference in Cytoscape

MOTIVATION Research on methods for the inference of networks from biological data is making significant advances, but the adoption of network inference in biomedical research practice is lagging behind. Here, we present Cyni, an open-source 'fill-in-the-algorithm' framework that provides common network inference functionality and user interface elements. Cyni allows the rapid transformation of ...

متن کامل

WikiPathways App for Cytoscape: Making biological pathways

In this paper we present the open-source WikiPathways app for Cytoscape ( ) that can be used to import http://apps.cytoscape.org/apps/wikipathways biological pathways for data visualization and network analysis. WikiPathways is an open, collaborative biological pathway database that provides fully annotated pathway diagrams for manual download or through web services. The WikiPathways app allow...

متن کامل

DeDaL: Cytoscape 3.0 app for producing and morphing data-driven and structure-driven network layouts

Background: Visualization and analysis of molecular profiling data together with biological networks are able to provide new mechanistical insights into biological functions. Currently, high-throughput data are usually visualized on top of predefined network layouts which are not always adapted to a given data analysis task. We developed a Cytoscape app which allows to construct biological netw...

متن کامل

Cytoscape App Store

SUMMARY Cytoscape is an open source software tool for biological network visualization and analysis, which can be extended with independently developed apps. We launched the Cytoscape App Store to highlight the important features that apps add to Cytoscape, enable researchers to find and install apps they need and help developers promote their apps. AVAILABILITY The App Store is available at ...

متن کامل

NOA: a cytoscape plugin for network ontology analysis

SUMMARY The Network Ontology Analysis (NOA) plugin for Cytoscape implements the NOA algorithm for network-based enrichment analysis, which extends Gene Ontology annotations to network links, or edges. The plugin facilitates the annotation and analysis of one or more networks in Cytoscape according to user-defined parameters. In addition to tables, the NOA plugin also presents results in the for...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Bioinformatics

دوره 31 2  شماره 

صفحات  -

تاریخ انتشار 2015